A randomized, phase 2 clinical trial of lithium carbonate in Machado-Joseph disease.
Identifieur interne : 000681 ( Main/Exploration ); précédent : 000680; suivant : 000682A randomized, phase 2 clinical trial of lithium carbonate in Machado-Joseph disease.
Auteurs : Jonas Alex Morales Saute [Brésil] ; Raphael Machado De Castilhos ; Thais Lampert Monte ; Artur Francisco Schumacher-Schuh ; Karina Carvalho Donis ; Rui D'Ávila ; Gabriele Nunes Souza ; Aline Dutra Russo ; Gabriel Vasata Furtado ; Tailise Conte Gheno ; Diogo Onofre Gomes De Souza ; Luis Valmor Cruz Portela ; Maria-Luiza Saraiva-Pereira ; Suzi Alvez Camey ; Vanessa Bielefeld Leotti Torman ; Carlos Roberto De Mello Rieder ; Laura Bannach JardimSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Enzyme Inhibitors, Lithium Carbonate.
- chemical , therapeutic use : Enzyme Inhibitors, Lithium Carbonate.
- drug therapy : Machado-Joseph Disease.
- Adult, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Because lithium exerts neuroprotective effects in preclinical models of polyglutamine disorders, our objective was to assess the safety and efficacy of lithium carbonate (0.5-0.8 milliequivalents per liter) in patients with Machado-Joseph disease (spinocerebellar ataxia type 3 [MJD/SCA3]).
DOI: 10.1002/mds.25803
PubMed: 24399647
Affiliations:
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when="2014">2014</date><idno type="RBID">pubmed:24399647</idno><idno type="pmid">24399647</idno><idno type="doi">10.1002/mds.25803</idno><idno type="wicri:Area/PubMed/Corpus">000612</idno><idno type="wicri:Area/PubMed/Curation">000612</idno><idno type="wicri:Area/PubMed/Checkpoint">000700</idno><idno type="wicri:Area/Ncbi/Merge">003E85</idno><idno type="wicri:Area/Ncbi/Curation">003E85</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E85</idno><idno type="wicri:Area/Main/Merge">000681</idno><idno type="wicri:Area/Main/Curation">000681</idno><idno type="wicri:Area/Main/Exploration">000681</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A randomized, phase 2 clinical trial of lithium carbonate in Machado-Joseph disease.</title><author><name sortKey="Saute, Jonas Alex Morales" sort="Saute, Jonas Alex Morales" uniqKey="Saute J" first="Jonas Alex Morales" last="Saute">Jonas Alex Morales Saute</name><affiliation wicri:level="2"><nlm:affiliation>Postgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Medical Genetics, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Postgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Medical Genetics, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="De Castilhos, Raphael Machado" sort="De Castilhos, Raphael Machado" uniqKey="De Castilhos R" first="Raphael Machado" last="De Castilhos">Raphael Machado De Castilhos</name></author><author><name sortKey="Monte, Thais Lampert" sort="Monte, Thais Lampert" uniqKey="Monte T" first="Thais Lampert" last="Monte">Thais Lampert Monte</name></author><author><name sortKey="Schumacher Schuh, Artur Francisco" sort="Schumacher Schuh, Artur Francisco" uniqKey="Schumacher Schuh A" first="Artur Francisco" last="Schumacher-Schuh">Artur Francisco Schumacher-Schuh</name></author><author><name sortKey="Donis, Karina Carvalho" sort="Donis, Karina Carvalho" uniqKey="Donis K" first="Karina Carvalho" last="Donis">Karina Carvalho Donis</name></author><author><name sortKey="D Vila, Rui" sort="D Vila, Rui" uniqKey="D Vila R" first="Rui" last="D'Ávila">Rui D'Ávila</name></author><author><name sortKey="Souza, Gabriele Nunes" sort="Souza, Gabriele Nunes" uniqKey="Souza G" first="Gabriele Nunes" last="Souza">Gabriele Nunes Souza</name></author><author><name sortKey="Russo, Aline Dutra" sort="Russo, Aline Dutra" uniqKey="Russo A" first="Aline Dutra" last="Russo">Aline Dutra Russo</name></author><author><name sortKey="Furtado, Gabriel Vasata" sort="Furtado, Gabriel Vasata" uniqKey="Furtado G" first="Gabriel Vasata" last="Furtado">Gabriel Vasata Furtado</name></author><author><name sortKey="Gheno, Tailise Conte" sort="Gheno, Tailise Conte" uniqKey="Gheno T" first="Tailise Conte" last="Gheno">Tailise Conte Gheno</name></author><author><name sortKey="De Souza, Diogo Onofre Gomes" sort="De Souza, Diogo Onofre Gomes" uniqKey="De Souza D" first="Diogo Onofre Gomes" last="De Souza">Diogo Onofre Gomes De Souza</name></author><author><name sortKey="Portela, Luis Valmor Cruz" sort="Portela, Luis Valmor Cruz" uniqKey="Portela L" first="Luis Valmor Cruz" last="Portela">Luis Valmor Cruz Portela</name></author><author><name sortKey="Saraiva Pereira, Maria Luiza" sort="Saraiva Pereira, Maria Luiza" uniqKey="Saraiva Pereira M" first="Maria-Luiza" last="Saraiva-Pereira">Maria-Luiza Saraiva-Pereira</name></author><author><name sortKey="Camey, Suzi Alvez" sort="Camey, Suzi Alvez" uniqKey="Camey S" first="Suzi Alvez" last="Camey">Suzi Alvez Camey</name></author><author><name sortKey="Torman, Vanessa Bielefeld Leotti" sort="Torman, Vanessa Bielefeld Leotti" uniqKey="Torman V" first="Vanessa Bielefeld Leotti" last="Torman">Vanessa Bielefeld Leotti Torman</name></author><author><name sortKey="De Mello Rieder, Carlos Roberto" sort="De Mello Rieder, Carlos Roberto" uniqKey="De Mello Rieder C" first="Carlos Roberto" last="De Mello Rieder">Carlos Roberto De Mello Rieder</name></author><author><name sortKey="Jardim, Laura Bannach" sort="Jardim, Laura Bannach" uniqKey="Jardim L" first="Laura Bannach" last="Jardim">Laura Bannach Jardim</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Enzyme Inhibitors (adverse effects)</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Female</term><term>Humans</term><term>Lithium Carbonate (adverse effects)</term><term>Lithium Carbonate (therapeutic use)</term><term>Machado-Joseph Disease (drug therapy)</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Enzyme Inhibitors</term><term>Lithium Carbonate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Enzyme Inhibitors</term><term>Lithium Carbonate</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Machado-Joseph Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Because lithium exerts neuroprotective effects in preclinical models of polyglutamine disorders, our objective was to assess the safety and efficacy of lithium carbonate (0.5-0.8 milliequivalents per liter) in patients with Machado-Joseph disease (spinocerebellar ataxia type 3 [MJD/SCA3]).</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Rio Grande do Sul</li></region></list><tree><noCountry><name sortKey="Camey, Suzi Alvez" sort="Camey, Suzi Alvez" uniqKey="Camey S" first="Suzi Alvez" last="Camey">Suzi Alvez Camey</name><name sortKey="D Vila, Rui" sort="D Vila, Rui" uniqKey="D Vila R" first="Rui" last="D'Ávila">Rui D'Ávila</name><name sortKey="De Castilhos, Raphael Machado" sort="De Castilhos, Raphael Machado" uniqKey="De Castilhos R" first="Raphael Machado" last="De Castilhos">Raphael Machado De Castilhos</name><name sortKey="De Mello Rieder, Carlos Roberto" sort="De Mello Rieder, Carlos Roberto" uniqKey="De Mello Rieder C" first="Carlos Roberto" last="De Mello Rieder">Carlos Roberto De Mello Rieder</name><name sortKey="De Souza, Diogo Onofre Gomes" sort="De Souza, Diogo Onofre Gomes" uniqKey="De Souza D" first="Diogo Onofre Gomes" last="De Souza">Diogo Onofre Gomes De Souza</name><name sortKey="Donis, Karina Carvalho" sort="Donis, Karina Carvalho" uniqKey="Donis K" first="Karina Carvalho" last="Donis">Karina Carvalho Donis</name><name sortKey="Furtado, Gabriel Vasata" sort="Furtado, Gabriel Vasata" uniqKey="Furtado G" first="Gabriel Vasata" last="Furtado">Gabriel Vasata Furtado</name><name sortKey="Gheno, Tailise Conte" sort="Gheno, Tailise Conte" uniqKey="Gheno T" first="Tailise Conte" last="Gheno">Tailise Conte Gheno</name><name sortKey="Jardim, Laura Bannach" sort="Jardim, Laura Bannach" uniqKey="Jardim L" first="Laura Bannach" last="Jardim">Laura Bannach Jardim</name><name sortKey="Monte, Thais Lampert" sort="Monte, Thais Lampert" uniqKey="Monte T" first="Thais Lampert" last="Monte">Thais Lampert Monte</name><name sortKey="Portela, Luis Valmor Cruz" sort="Portela, Luis Valmor Cruz" uniqKey="Portela L" first="Luis Valmor Cruz" last="Portela">Luis Valmor Cruz Portela</name><name sortKey="Russo, Aline Dutra" sort="Russo, Aline Dutra" uniqKey="Russo A" first="Aline Dutra" last="Russo">Aline Dutra Russo</name><name sortKey="Saraiva Pereira, Maria Luiza" sort="Saraiva Pereira, Maria Luiza" uniqKey="Saraiva Pereira M" first="Maria-Luiza" last="Saraiva-Pereira">Maria-Luiza Saraiva-Pereira</name><name sortKey="Schumacher Schuh, Artur Francisco" sort="Schumacher Schuh, Artur Francisco" uniqKey="Schumacher Schuh A" first="Artur Francisco" last="Schumacher-Schuh">Artur Francisco Schumacher-Schuh</name><name sortKey="Souza, Gabriele Nunes" sort="Souza, Gabriele Nunes" uniqKey="Souza G" first="Gabriele Nunes" last="Souza">Gabriele Nunes Souza</name><name sortKey="Torman, Vanessa Bielefeld Leotti" sort="Torman, Vanessa Bielefeld Leotti" uniqKey="Torman V" first="Vanessa Bielefeld Leotti" last="Torman">Vanessa Bielefeld Leotti Torman</name></noCountry><country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Saute, Jonas Alex Morales" sort="Saute, Jonas Alex Morales" uniqKey="Saute J" first="Jonas Alex Morales" last="Saute">Jonas Alex Morales Saute</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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